Differences in N-glycosylation of recombinant human coagulation factor VII derived from BHK, CHO, and HEK293 cells

BACKGROUND & METHODS: Recombinant factor VII (rFVII), the precursor molecule for recombinant activated FVII (rFVIIa), is, due to its need for complex post translational modifications, produced in mammalian cells. To evaluate the suitability of a human cell line in order to produce rFVII with pos...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:BMC Biotechnol
Asıl Yazarlar: Böhm, Ernst, Seyfried, Birgit K., Dockal, Michael, Graninger, Michael, Hasslacher, Meinhard, Neurath, Marianne, Konetschny, Christian, Matthiessen, Peter, Mitterer, Artur, Scheiflinger, Friedrich
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2015
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574471/
https://ncbi.nlm.nih.gov/pubmed/26382581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-015-0205-1
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