Differences in N-glycosylation of recombinant human coagulation factor VII derived from BHK, CHO, and HEK293 cells

BACKGROUND & METHODS: Recombinant factor VII (rFVII), the precursor molecule for recombinant activated FVII (rFVIIa), is, due to its need for complex post translational modifications, produced in mammalian cells. To evaluate the suitability of a human cell line in order to produce rFVII with pos...

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Detalhes bibliográficos
Publicado no:BMC Biotechnol
Main Authors: Böhm, Ernst, Seyfried, Birgit K., Dockal, Michael, Graninger, Michael, Hasslacher, Meinhard, Neurath, Marianne, Konetschny, Christian, Matthiessen, Peter, Mitterer, Artur, Scheiflinger, Friedrich
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574471/
https://ncbi.nlm.nih.gov/pubmed/26382581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12896-015-0205-1
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