Activation of Src-dependent Smad3 signaling mediates the neutrophilic inflammation and oxidative stress in hyperoxia-augmented ventilator-induced lung injury

BACKGROUND: Mechanical ventilation and concomitant administration of hyperoxia in patients with acute respiratory distress syndrome can damage the alveolar epithelial and capillary endothelial barrier by producing inflammatory cytokines and reactive oxygen species. The Src tyrosine kinase and Smad3...

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Vydáno v:Respir Res
Hlavní autoři: Li, Li-Fu, Lee, Chung-Shu, Liu, Yung-Yang, Chang, Chih-Hao, Lin, Chang-Wei, Chiu, Li-Chung, Kao, Kuo-Chin, Chen, Ning-Hung, Yang, Cheng-Ta
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574227/
https://ncbi.nlm.nih.gov/pubmed/26377087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-015-0275-6
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