Delivery of antisense oligonucleotides using poly(alkylene oxide)-poly(propylacrylic acid) graft copolymers in conjunction with cationic liposomes

The clinical application of gene silencing is hindered by poor stability and low delivery efficiency of naked oligonucleotides. Here, we present the in vitro and in vivo behavior of a rationally designed, ternary, self-assembled nanoparticle complex, consisting of an anionic copolymer, cationic DOTA...

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Detaylı Bibliyografya
Yayımlandı:J Control Release
Asıl Yazarlar: Peddada, Lavanya Y., Garbuzenko, Olga B., Devore, David I., Minko, Tamara, Roth, Charles M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4573985/
https://ncbi.nlm.nih.gov/pubmed/25192941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.08.023
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