Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response

BACKGROUND: The genome-wide hyperacetylation of chromatin caused by histone deacetylase inhibitors (HDACi) is surprisingly well tolerated by most eukaryotic cells. The homeostatic mechanisms that underlie this tolerance are unknown. Here we identify the transcriptional and epigenomic changes that co...

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Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: Halsall, John A, Turan, Nil, Wiersma, Maaike, Turner, Bryan M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4572612/
https://ncbi.nlm.nih.gov/pubmed/26380582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-015-0021-9
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