A Metabolic Shift toward Pentose Phosphate Pathway Is Necessary for Amyloid Fibril- and Phorbol 12-Myristate 13-Acetate-induced Neutrophil Extracellular Trap (NET) Formation

Neutrophils are the main defense cells of the innate immune system. Upon stimulation, neutrophils release their chromosomal DNA to trap and kill microorganisms and inhibit their dissemination. These chromatin traps are termed neutrophil extracellular traps (NETs) and are decorated with granular and...

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Udgivet i:J Biol Chem
Main Authors: Azevedo, Estefania P., Rochael, Natalia C., Guimarães-Costa, Anderson B., de Souza-Vieira, Thiago S., Ganilho, Juliana, Saraiva, Elvira M., Palhano, Fernando L., Foguel, Debora
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571968/
https://ncbi.nlm.nih.gov/pubmed/26198639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.640094
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