Amyloid Fibrils Trigger the Release of Neutrophil Extracellular Traps (NETs), Causing Fibril Fragmentation by NET-associated Elastase

The accumulation of amyloid fibrils is a feature of amyloid diseases, where cell toxicity is due to soluble oligomeric species that precede fibril formation or are formed by fibril fragmentation, but the mechanism(s) of fragmentation is still unclear. Neutrophil-derived elastase and histones were fo...

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Detalhes bibliográficos
Main Authors: Azevedo, Estefania P. C., Guimarães-Costa, Anderson B., Torezani, Guilherme S., Braga, Carolina A., Palhano, Fernando L., Kelly, Jeffery W., Saraiva, Elvira M., Foguel, Debora
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481320/
https://ncbi.nlm.nih.gov/pubmed/22918834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.369942
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