Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1

[Image: see text] Pancreatic-type ribonucleases are secretory enzymes that catalyze the cleavage of RNA. Recent efforts have endowed the homologues from cow (RNase A) and human (RNase 1) with toxicity for cancer cells, leading to a clinical trial. The basis for the selective toxicity of ribonuclease...

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Bibliographic Details
Published in:ACS Cent Sci
Main Authors: Eller, Chelcie H., Chao, Tzu-Yuan, Singarapu, Kiran K., Ouerfelli, Ouathek, Yang, Guangbin, Markley, John L., Danishefsky, Samuel J., Raines, Ronald T.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2015
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571170/
https://ncbi.nlm.nih.gov/pubmed/26405690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.5b00164
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