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DNA-Encoded Solid-Phase Synthesis: Encoding Language Design and Complex Oligomer Library Synthesis

[Image: see text] The promise of exploiting combinatorial synthesis for small molecule discovery remains unfulfilled due primarily to the “structure elucidation problem”: the back-end mass spectrometric analysis that significantly restricts one-bead-one-compound (OBOC) library complexity. The very m...

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Vydáno v:ACS Comb Sci
Hlavní autoři: MacConnell, Andrew B., McEnaney, Patrick J., Cavett, Valerie J., Paegel, Brian M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2015
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571006/
https://ncbi.nlm.nih.gov/pubmed/26290177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.5b00106
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