Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium

Acetaldehyde is an ethanol-derived definite carcinogen that causes oesophageal squamous cell carcinoma (ESCC). Aldehyde dehydrogenase 2 (ALDH2) is a key enzyme that eliminates acetaldehyde, and impairment of ALDH2 increases the risk of ESCC. ALDH2 is produced in various tissues including the liver,...

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Publicat a:Sci Rep
Autors principals: Amanuma, Yusuke, Ohashi, Shinya, Itatani, Yoshiro, Tsurumaki, Mihoko, Matsuda, Shun, Kikuchi, Osamu, Nakai, Yukie, Miyamoto, Shin’ichi, Oyama, Tsunehiro, Kawamoto, Toshihiro, Whelan, Kelly A., Nakagawa, Hiroshi, Chiba, Tsutomu, Matsuda, Tomonari, Muto, Manabu
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570974/
https://ncbi.nlm.nih.gov/pubmed/26374466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep14142
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