Competition Between α-Actinin and Ca(2+)-Calmodulin Controls Surface Retention of the L-type Ca(2+) Channel Ca(V)1.2

Regulation of neuronal excitability and cardiac excitation-contraction coupling requires proper localization of L-type Ca(2+) channels. We show that the actin-binding protein α-actinin binds to the C-terminal surface targeting motif of α(1)1.2, the central pore-forming Ca(V)1.2 subunit, to foster it...

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Publicado no:Neuron
Main Authors: Hall, Duane D., Dai, Shuiping, Tseng, Pang-Yen, Malik, Zulfiqar, Nguyen, Minh, Matt, Lucas M., Schnizler, Katrin, Shephard, Andrew, Mohapatra, Durga P., Tsuruta, Fuminori, Dolmetsch, Ricardo E., Christel, Carl J., Lee, Amy, Burette, Alain, Weinberg, Richard J., Hell, Johannes W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570828/
https://ncbi.nlm.nih.gov/pubmed/23664615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2013.02.032
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