Engineering a poliovirus type 2 antigenic site on a type 1 capsid results in a chimaeric virus which is neurovirulent for mice.

Poliovirus type 2 (PV-2) Lansing strain produces a fatal paralytic disease in mice after intracerebral injection, whereas poliovirus type 1 (PV-1) Mahoney strain causes disease only in primates. Atomic models derived from the three-dimensional crystal structure of the PV-1 Mahoney strain have been u...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Martin, A, Wychowski, C, Couderc, T, Crainic, R, Hogle, J, Girard, M
Format: Artigo
Jezik:Inglês
Izdano: 1988
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC457076/
https://ncbi.nlm.nih.gov/pubmed/2460345
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki