Engineering a poliovirus type 2 antigenic site on a type 1 capsid results in a chimaeric virus which is neurovirulent for mice.

Poliovirus type 2 (PV-2) Lansing strain produces a fatal paralytic disease in mice after intracerebral injection, whereas poliovirus type 1 (PV-1) Mahoney strain causes disease only in primates. Atomic models derived from the three-dimensional crystal structure of the PV-1 Mahoney strain have been u...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Martin, A, Wychowski, C, Couderc, T, Crainic, R, Hogle, J, Girard, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1988
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC457076/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2460345/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1988.tb03140.x
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