A nanoparticle formula for delivering siRNA or miRNAs to tumor cells in cell culture and in vivo

To improve RNA delivery, we present a protocol to produce an RNA carrier based on a Zn(II)-dipicolylamine (Zn-DPA) analog, which is an artificial receptor for phosphate anion derivatives. We further functionalized this Zn-DPA analog to hyaluronic acid (HA)-based self-assembled nanoparticles (HA-NPS)...

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Detalles Bibliográficos
Publicado en:Nat Protoc
Main Authors: Choi, Ki Young, Silvestre, Oscar F, Huang, Xinglu, Hida, Naoki, Liu, Gang, Ho, Don N, Lee, Seulki, Lee, Sang Wook, Hong, Jong In, Chen, Xiaoyuan
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570470/
https://ncbi.nlm.nih.gov/pubmed/25033207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2014.128
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