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Tumor-infiltrating myeloid cells drive senescence evasion and chemoresistance in tumors
The present study supports a model in which Pten loss-induced senescence is hindered in prostate tumor cells by non cell-autonomous mechanisms. Indeed, paracrine signaling by tumor-infiltrating CD11b(+)Gr-1(+) myeloid cells triggers senescence evasion in prostate lesions of Pten-null mice, eventuall...
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| Gepubliceerd in: | Oncoimmunology |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Taylor & Francis
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4570142/ https://ncbi.nlm.nih.gov/pubmed/26405613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/2162402X.2014.988473 |
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