A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism

Respiratory syncytial virus (RSV) causes acute lower respiratory tract infections and is the leading cause of infant hospitalizations. Recently, a promising vaccine antigen based on the RSV fusion protein (RSV F) stabilized in the native prefusion conformation has been described. Here we report alte...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Krarup, Anders, Truan, Daphné, Furmanova-Hollenstein, Polina, Bogaert, Lies, Bouchier, Pascale, Bisschop, Ilona J. M., Widjojoatmodjo, Myra N., Zahn, Roland, Schuitemaker, Hanneke, McLellan, Jason S., Langedijk, Johannes P. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Pub. Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569726/
https://ncbi.nlm.nih.gov/pubmed/26333350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9143
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