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Pseudomonas aeruginosa Uses Dihydrolipoamide Dehydrogenase (Lpd) to Bind to the Human Terminal Pathway Regulators Vitronectin and Clusterin to Inhibit Terminal Pathway Complement Attack

The opportunistic human pathogen Pseudomonas aeruginosa controls host innate immune and complement attack. Here we identify Dihydrolipoamide dehydrogenase (Lpd), a 57 kDa moonlighting protein, as the first P. aeruginosa protein that binds the two human terminal pathway inhibitors vitronectin and clu...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Hallström, Teresia, Uhde, Melanie, Singh, Birendra, Skerka, Christine, Riesbeck, Kristian, Zipfel, Peter F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4569481/
https://ncbi.nlm.nih.gov/pubmed/26368530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137630
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