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A Fine-Tuned Interaction between Trimeric Autotransporter Haemophilus Surface Fibrils and Vitronectin Leads to Serum Resistance and Adherence to Respiratory Epithelial Cells

Haemophilus influenzae type b (Hib) escapes the host immune system by recruitment of the complement regulator vitronectin, which inhibits the formation of the membrane attack complex (MAC) by inhibiting C5b-C7 complex formation and C9 polymerization. We reported previously that Hib acquires vitronec...

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Autori principali: Singh, Birendra, Su, Yu-Ching, Al-Jubair, Tamim, Mukherjee, Oindrilla, Hallström, Teresia, Mörgelin, Matthias, Blom, Anna M., Riesbeck, Kristian
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019195/
https://ncbi.nlm.nih.gov/pubmed/24664511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01636-13
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