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A Rescue Strategy for Handling Unevaluable Patients in Simon’s Two Stage Design
For phase II oncology trials, Simon’s two-stage design is the most commonly used strategy. However, when clinically unevaluable patients occur, the total number of patients included at each stage differs from what was initially planned. Such situations raise concerns about the operating characterist...
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| 出版年: | PLoS One |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4569274/ https://ncbi.nlm.nih.gov/pubmed/26368810 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137586 |
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