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Approaches to Handling Data When a Phase II Trial Deviates from the Pre-specified Simon's Two-Stage Design
Simon's ‘optimal’ and ‘minimax’ two-stage designs are common methods for conducting phase IIA studies investigating new cancer therapies. However, these designs are rather rigid in their settings because of the pre-specified rejection rules and fixed sample sizes at each stage. In practice, we...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2678911/ https://ncbi.nlm.nih.gov/pubmed/18800338 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.3426 |
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