ALS/FTD phenotype in two Sardinian families carrying both C9ORF72 and TARDBP mutations

BACKGROUND: In the isolated population of Sardinia, a Mediterranean island, ~25% of ALS cases carry either a p.A382T mutation of the TARDBP gene or a GGGGCC hexanucleotide repeat expansion in the first intron of the C9ORF72 gene. OBJECTIVE: To describe the co-presence of two genetic mutations in two...

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Publicado en:J Neurol Neurosurg Psychiatry
Autores principales: Chiò, Adriano, Restagno, Gabriella, Brunetti, Maura, Ossola, Irene, Calvo, Andrea, Canosa, Antonio, Moglia, Cristina, Floris, Gianluca, Tacconi, Paolo, Marrosu, Francesco, Marrosu, Maria Giovanna, Murru, Maria Rita, Majounie, Elisa, Renton, Alan E, Abramzon, Yvegeniya, Pugliatti, Maura, Sotgiu, Maria Alessandra, Traynor, Bryan J, Borghero, Giuseppe
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568835/
https://ncbi.nlm.nih.gov/pubmed/22550220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2012-302219
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