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Chemical Analysis of Drug Biocrystals: A Role for Counterion Transport Pathways in Intracellular Drug Disposition

In mammals, highly lipophilic small molecule chemical agents can accumulate as inclusions within resident tissue macrophages. In this context, we characterized the biodistribution, chemical composition and structure of crystal-like drug inclusions (CLDIs) formed by clofazimine (CFZ), a weakly basic...

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Détails bibliographiques
Publié dans:Mol Pharm
Auteurs principaux: Keswani, Rahul K., Baik, Jason, Yeomans, Larisa, Hitzman, Chuck, Johnson, Allison, Pawate, Ashtamurthy, Kenis, Paul J. A., Rodriguez-Hornedo, Nair, Stringer, Kathleen A., Rosania, Gus R.
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568831/
https://ncbi.nlm.nih.gov/pubmed/25926092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00032
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