Chemical Analysis of Drug Biocrystals: A Role for Counterion Transport Pathways in Intracellular Drug Disposition

In mammals, highly lipophilic small molecule chemical agents can accumulate as inclusions within resident tissue macrophages. In this context, we characterized the biodistribution, chemical composition and structure of crystal-like drug inclusions (CLDIs) formed by clofazimine (CFZ), a weakly basic...

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Udgivet i:Mol Pharm
Main Authors: Keswani, Rahul K., Baik, Jason, Yeomans, Larisa, Hitzman, Chuck, Johnson, Allison, Pawate, Ashtamurthy, Kenis, Paul J. A., Rodriguez-Hornedo, Nair, Stringer, Kathleen A., Rosania, Gus R.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568831/
https://ncbi.nlm.nih.gov/pubmed/25926092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00032
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