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Mitochondrial calcium overload is a key determinant in heart failure
Calcium (Ca(2+)) released from the sarcoplasmic reticulum (SR) is crucial for excitation–contraction (E–C) coupling. Mitochondria, the major source of energy, in the form of ATP, required for cardiac contractility, are closely interconnected with the SR, and Ca(2+) is essential for optimal function...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4568687/ https://ncbi.nlm.nih.gov/pubmed/26217001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513047112 |
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