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Mitochondrial calcium overload is a key determinant in heart failure
Calcium (Ca(2+)) released from the sarcoplasmic reticulum (SR) is crucial for excitation–contraction (E–C) coupling. Mitochondria, the major source of energy, in the form of ATP, required for cardiac contractility, are closely interconnected with the SR, and Ca(2+) is essential for optimal function...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4568687/ https://ncbi.nlm.nih.gov/pubmed/26217001 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513047112 |
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