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Playing POLO-like kinase in NRAS mutant melanoma

NRAS-mutant melanomas are extremely aggressive and highly resistant to currently available therapeutic modalities. Hence, new targets and therapeutic strategies for NRAS-driven melanomas are needed. As blocking NRAS directly has not been possible thus far, targeting downstream NRAS effectors, such a...

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Publicat a:J Invest Dermatol
Autors principals: Chen, Hsin-Yi, Villanueva, Jessie
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568563/
https://ncbi.nlm.nih.gov/pubmed/26358384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2015.253
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