Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination

Melanoma is difficult to treat once it becomes metastatic. However, the precise ancestral relationship between primary tumors and their metastases is not well understood. We performed whole-exome sequencing of primary melanomas and multiple matched metastases from eight patients to elucidate their p...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sanborn, J. Zachary, Chung, Jongsuk, Purdom, Elizabeth, Wang, Nicholas J., Kakavand, Hojabr, Wilmott, James S., Butler, Timothy, Thompson, John F., Mann, Graham J., Haydu, Lauren E., Saw, Robyn P. M., Busam, Klaus J., Lo, Roger S., Collisson, Eric A., Hur, Joe S., Spellman, Paul T., Cleaver, James E., Gray, Joe W., Huh, Nam, Murali, Rajmohan, Scolyer, Richard A., Bastian, Boris C., Cho, Raymond J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568214/
https://ncbi.nlm.nih.gov/pubmed/26286987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508074112
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