Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination

Melanoma is difficult to treat once it becomes metastatic. However, the precise ancestral relationship between primary tumors and their metastases is not well understood. We performed whole-exome sequencing of primary melanomas and multiple matched metastases from eight patients to elucidate their p...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Sanborn, J. Zachary, Chung, Jongsuk, Purdom, Elizabeth, Wang, Nicholas J., Kakavand, Hojabr, Wilmott, James S., Butler, Timothy, Thompson, John F., Mann, Graham J., Haydu, Lauren E., Saw, Robyn P. M., Busam, Klaus J., Lo, Roger S., Collisson, Eric A., Hur, Joe S., Spellman, Paul T., Cleaver, James E., Gray, Joe W., Huh, Nam, Murali, Rajmohan, Scolyer, Richard A., Bastian, Boris C., Cho, Raymond J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568214/
https://ncbi.nlm.nih.gov/pubmed/26286987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1508074112
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