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Continuum Model of T-cell Avidity: Understanding Autoreactive and Regulatory T-Cell Responses in Type 1 Diabetes
Type 1 diabetes (T1D) is an autoimmune disease that results from the destruction of insulin-secreting pancreatic β cells, leading to abolition of insulin secretion and onset of diabetes. Cytotoxic CD4(+) and CD8(+) T cells, activated by antigen presenting cells (APCs), are both implicated in disease...
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| Publicado no: | J Theor Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4567915/ https://ncbi.nlm.nih.gov/pubmed/26271890 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2015.07.032 |
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