Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells

BACKGROUND: Ursolic acid (UA), a pentacyclic triterpenoid, is known to have anti-tumor activity in various cancers including human non small cell lung cancer (NSCLC). However, the molecular mechanisms underlying the action of UA remain largely unknown. METHODS: Cell viability was measured by MTT ass...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Wu, Jingjing, Zhao, Shunyu, Tang, Qing, Zheng, Fang, Chen, YuQin, Yang, LiJun, Yang, Xiaobing, Li, Liuning, Wu, WanYin, Hann, Swei Sunny
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567809/
https://ncbi.nlm.nih.gov/pubmed/26362062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-015-0215-9
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