Deficiency of Angiotensinogen in Hepatocytes Markedly Decreases Blood Pressure in Lean and Obese Male Mice

We recently demonstrated that adipocyte deficiency of angiotensinogen ablated high fat diet-induced elevations in plasma angiotensin II concentrations and obesity-hypertension in male mice. Hepatocytes are the predominant source of systemic angiotensinogen. Therefore, in this study, we defined the c...

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Detalhes bibliográficos
Publicado no:Hypertension
Principais autores: Yiannikouris, Frederique, Wang, Yu, Shoemaker, Robin, Larian, Nika, Thompson, Joel, English, Victoria L., Charnigo, Richard, Su, Wen, Gong, Ming, Cassis, Lisa A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567497/
https://ncbi.nlm.nih.gov/pubmed/26303292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.115.06040
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