TLR9 Mediates Remote Liver Injury following Severe Renal Ischemia Reperfusion

Ischemia reperfusion injury is a common cause of acute kidney injury and is characterized by tubular damage. Mitochondrial DNA is released upon severe tissue injury and can act as a damage-associated molecular pattern via the innate immune receptor TLR9. Here, we investigated the role of TLR9 in the...

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Pubblicato in:PLoS One
Autori principali: Bakker, Pieter J., Scantlebery, Angelique M., Butter, Loes M., Claessen, Nike, Teske, Gwendoline J. D., van der Poll, Tom, Florquin, Sandrine, Leemans, Jaklien C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567139/
https://ncbi.nlm.nih.gov/pubmed/26361210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137511
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