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Loss of 5-hydroxymethylcytosine in cancer: cause or consequence?
Discovery of the enzymatic activity that catalyses oxidation of 5-methylcytosine (5mC) to generate 5-hydroxymethylcytosine (5hmC) mediated by the MLL fusion partner TET1 has sparked intense research to understand the role this new DNA modification has in cancer. An unambiguous picture has emerged wh...
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| Veröffentlicht in: | Genomics |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4566966/ https://ncbi.nlm.nih.gov/pubmed/25179374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygeno.2014.08.017 |
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