Macitentan inhibits the transforming growth factor-β profibrotic action, blocking the signaling mediated by the ETR/TβRI complex in systemic sclerosis dermal fibroblasts

INTRODUCTION: Systemic sclerosis (SSc) is a complex and not fully understood autoimmune disease associated with fibrosis of multiple organs. The main effector cells, the myofibroblasts, are collagen-producing cells derived from the activation of resting fibroblasts. This process is regulated by a co...

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Veröffentlicht in:Arthritis Res Ther
Hauptverfasser: Cipriani, Paola, Di Benedetto, Paola, Ruscitti, Piero, Verzella, Daniela, Fischietti, Mariafausta, Zazzeroni, Francesca, Liakouli, Vasiliki, Carubbi, Francesco, Berardicurti, Onorina, Alesse, Edoardo, Giacomelli, Roberto
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566861/
https://ncbi.nlm.nih.gov/pubmed/26357964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0754-7
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