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Macitentan inhibits the transforming growth factor-β profibrotic action, blocking the signaling mediated by the ETR/TβRI complex in systemic sclerosis dermal fibroblasts
INTRODUCTION: Systemic sclerosis (SSc) is a complex and not fully understood autoimmune disease associated with fibrosis of multiple organs. The main effector cells, the myofibroblasts, are collagen-producing cells derived from the activation of resting fibroblasts. This process is regulated by a co...
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Publicat a: | Arthritis Res Ther |
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Autors principals: | , , , , , , , , , , |
Format: | Artigo |
Idioma: | Inglês |
Publicat: |
BioMed Central
2015
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Matèries: | |
Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4566861/ https://ncbi.nlm.nih.gov/pubmed/26357964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0754-7 |
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