Gene expression meta-analysis reveals immune response convergence on the IFNγ-STAT1-IRF1 axis and adaptive immune resistance mechanisms in lymphoma

BACKGROUND: Cancers adapt to immune-surveillance through evasion. Immune responses against carcinoma and melanoma converge on cytotoxic effectors and IFNγ-STAT1-IRF1 signalling. Local IFN-driven immune checkpoint expression can mediate feedback inhibition and adaptive immune resistance. Whether such...

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Publicat a:Genome Med
Autors principals: Care, Matthew A., Westhead, David R., Tooze, Reuben M.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2015
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566848/
https://ncbi.nlm.nih.gov/pubmed/26362649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-015-0218-3
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