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Cyclin-dependent Kinase-mediated Sox2 Phosphorylation Enhances the Ability of Sox2 to Establish the Pluripotent State

Sox2 is a key factor in maintaining self-renewal of embryonic stem cells (ESCs) and adult stem cells as well as in reprogramming differentiated cells back into pluripotent or multipotent stem cells. Although previous studies have shown that Sox2 is phosphorylated in human ESCs, the biological signif...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Ouyang, Juan, Yu, Wei, Liu, Jing, Zhang, Nian, Florens, Laurence, Chen, Jiekai, Liu, He, Washburn, Michael, Pei, Duanqing, Xie, Ting
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566249/
https://ncbi.nlm.nih.gov/pubmed/26139602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.658195
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