Enhanced Transfer of a Photocross-linking N-Acetylglucosamine (GlcNAc) Analog by an O-GlcNAc Transferase Mutant with Converted Substrate Specificity

O-Linked β-N-acetylglucosamine (O-GlcNAc) is a post-translational modification of proteins in multicellular organisms. O-GlcNAc modification is catalyzed by the O-GlcNAc transferase (OGT), which transfers N-acetylglucosamine (GlcNAc) from the nucleotide sugar donor UDP-GlcNAc to serine or threonine...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Rodriguez, Andrea C., Yu, Seok-Ho, Li, Bin, Zegzouti, Hicham, Kohler, Jennifer J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Glycobiology and Extracellular Matrices
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566237/
https://ncbi.nlm.nih.gov/pubmed/26240142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.667006
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