Altered Activation of Protein Kinase PKR and Enhanced Apoptosis in Dystonia Cells Carrying a Mutation in PKR Activator Protein PACT

PACT is a stress-modulated activator of the interferon-induced double-stranded RNA-activated protein kinase (PKR). Stress-induced phosphorylation of PACT is essential for PACT's association with PKR leading to PKR activation. PKR activation leads to phosphorylation of translation initiation fac...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Vaughn, Lauren S, Bragg, D. Cristopher, Sharma, Nutan, Camargos, Sarah, Cardoso, Francisco, Patel, Rekha C
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566229/
https://ncbi.nlm.nih.gov/pubmed/26231208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.669408
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