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Human Enhancers Are Fragile and Prone to Deactivating Mutations
To explore the underlying mechanisms whereby noncoding variants affect transcriptional regulation, we identified nucleotides capable of disrupting binding of transcription factors and deactivating enhancers if mutated (dubbed candidate killer mutations or KMs) in HepG2 enhancers. On average, approxi...
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| Veröffentlicht in: | Mol Biol Evol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4566102/ https://ncbi.nlm.nih.gov/pubmed/25976354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msv118 |
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