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Stable enhancers are active in development, and fragile enhancers are associated with evolutionary adaptation
BACKGROUND: Despite continual progress in the identification and characterization of trait- and disease-associated variants that disrupt transcription factor (TF)-DNA binding, little is known about the distribution of TF binding deactivating mutations (deMs) in enhancer sequences. Here, we focus on...
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| 出版年: | Genome Biol |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6631995/ https://ncbi.nlm.nih.gov/pubmed/31307522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-019-1750-z |
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