Cell-to-cell transmission of HIV-1 is required to trigger pyroptotic death of lymphoid tissue-derived CD4 T cells

The progressive depletion of CD4 T cells underlies clinical progression to AIDS in untreated HIV-infected subjects. Most dying CD4 T cells correspond to resting nonpermissive cells residing in lymphoid tissues. Death is due to an innate immune response against the incomplete cytosolic viral DNA inte...

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Publicado en:Cell Rep
Autores principales: Galloway, Nicole LK, Doitsh, Gilad, Monroe, Kathryn M., Yang, Zhiyuan, Muñoz-Arias, Isa, Levy, David N, Greene, Warner C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565731/
https://ncbi.nlm.nih.gov/pubmed/26321639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.011
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