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IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T-cells Abortively Infected with HIV

The progressive depletion of quiescent “bystander” CD4 T-cells, which are non-permissive to HIV infection, is a principal driver of the acquired immunodeficiency syndrome (AIDS). These cells undergo abortive infection characterized by the cytosolic accumulation of incomplete HIV reverse transcripts....

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Autors principals: Monroe, Kathryn M., Yang, Zhiyuan, Johnson, Jeffrey R., Geng, Xin, Doitsh, Gilad, Krogan, Nevan J., Greene, Warner C.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976200/
https://ncbi.nlm.nih.gov/pubmed/24356113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1243640
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