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Anticancer activity of the Aurora A kinase inhibitor MK-5108 in non-small-cell lung cancer (NSCLC) in vitro as monotherapy and in combination with chemotherapies

PURPOSE: Aurora kinases are key regulators of mitotic events. Dysfunction of these kinases can cause polyploidy and chromosomal instability, a contributor to tumorigenesis. MK-5108 is a potent inhibitor of Aurora A kinase that has shown preclinical potent activity in malignancies of breast, cervical...

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Détails bibliographiques
Publié dans:J Cancer Res Clin Oncol
Auteurs principaux: Chinn, Danielle C., Holland, William S., Mack, Philip C.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565522/
https://ncbi.nlm.nih.gov/pubmed/24756365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00432-014-1675-6
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