Reg4-Induced Mitogenesis Involves Akt-GSK3β-β-Catenin-TCF-4 Signaling in Human Colorectal Cancer

Upregulation of regenerating gene 4 (Reg4) is observed in many human gastrointestinal malignancies including colorectal cancer (CRC). We previously reported a Reg4-mediated induction of epidermal growth factor receptor-Akt-AP1 signaling regulating CRC cell apoptosis. However, the role of Reg4 in the...

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Pubblicato in:Mol Carcinog
Autori principali: Bishnupuri, Kumar S, Sainathan, Satheesh K, Bishnupuri, Kislay, Leahy, Devon R, Luo, Qizhi, Anant, Shrikant, Houchen, Courtney W, Dieckgraefe, Brian K
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4565142/
https://ncbi.nlm.nih.gov/pubmed/24151146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.22088
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