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The TLR7 ligand Imiquimod induces type I IFN and antimicrobial peptides to ameliorate DSS-induced acute colitis
BACKGROUND: The pathogenesis of inflammatory bowel disease (IBD) is associated with a dysregulated mucosal immune response. Certain stimulators of innate immunity (CpG DNA or GM-CSF) are reported to be anti-inflammatory in IBD. Toll-like receptor-7 (TLR7) is an important regulator of innate immunity...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3878618/ https://ncbi.nlm.nih.gov/pubmed/21953855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.21867 |
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