The TLR7 ligand Imiquimod induces type I IFN and antimicrobial peptides to ameliorate DSS-induced acute colitis

BACKGROUND: The pathogenesis of inflammatory bowel disease (IBD) is associated with a dysregulated mucosal immune response. Certain stimulators of innate immunity (CpG DNA or GM-CSF) are reported to be anti-inflammatory in IBD. Toll-like receptor-7 (TLR7) is an important regulator of innate immunity...

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Autori principali: Sainathan, Satheesh K., Bishnupuri, Kumar S., Aden, Konrad, Luo, Qizhi, Houchen, Courtney W., Anant, Shrikant, Dieckgraefe, Brian K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3878618/
https://ncbi.nlm.nih.gov/pubmed/21953855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ibd.21867
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