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Absorption, distribution, metabolism, and excretion of [(14)C]-labeled naloxegol in healthy subjects
Objective: To characterize the absorption, distribution, metabolism, and excretion of naloxegol, a PEGylated derivative of the µ-opioid antagonist naloxone, in healthy male subjects. Materials and methods: [(14)C]-Labeled naloxegol (27 mg, 3.43 MBq) was administered as an oral solution to 6 fasted s...
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| Publicado no: | Int J Clin Pharmacol Ther |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dustri-Verlag Dr. Karl Feistle
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4564822/ https://ncbi.nlm.nih.gov/pubmed/26329350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5414/CP202276 |
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