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Morphine Reduces Myocardial Infarct Size via Heat Shock Protein 90 in Rodents

Opioids reduce injury from myocardial ischemia-reperfusion in humans. In experimental models, this mechanism involves GSK3β inhibition. HSP90 regulates mitochondrial protein import, with GSK3β inhibition increasing HSP90 mitochondrial content. Therefore, we determined whether morphine-induced cardio...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Small, Bryce A., Lu, Yao, Hsu, Anna K., Gross, Garrett J., Gross, Eric R.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564588/
https://ncbi.nlm.nih.gov/pubmed/26413502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2015/129612
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