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DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2

Small cell lung cancer (SCLC) is an aggressive malignancy characterized by early metastasis, rapid development of resistance to chemotherapy, and genetic instability. This study profiles DNA methylation in SCLC, patient-derived xenografts (PDXs) and cell lines at single nucleotide resolution. DNA me...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Poirier, John T., Gardner, Eric E., Connis, Nick, Moreira, Andre L., de Stanchina, Elisa, Hann, Christine L., Rudin, Charles M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564363/
https://ncbi.nlm.nih.gov/pubmed/25746006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.38
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