DNA methylation in small cell lung cancer defines distinct disease subtypes and correlates with high expression of EZH2

Small cell lung cancer (SCLC) is an aggressive malignancy characterized by early metastasis, rapid development of resistance to chemotherapy, and genetic instability. This study profiles DNA methylation in SCLC, patient-derived xenografts (PDXs) and cell lines at single nucleotide resolution. DNA me...

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Veröffentlicht in:Oncogene
Hauptverfasser: Poirier, John T., Gardner, Eric E., Connis, Nick, Moreira, Andre L., de Stanchina, Elisa, Hann, Christine L., Rudin, Charles M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564363/
https://ncbi.nlm.nih.gov/pubmed/25746006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.38
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