High level MYCN amplification and distinct methylation signature define an aggressive subtype of spinal cord ependymoma

We report a novel group of clinically aggressive spinal cord ependymomas characterized by Grade III histology, MYCN amplification, an absence of NF2 alterations or other recurrent pathogenic mutations, and a unique methylation classifier profile. Seven cases were found to have MYCN amplification in...

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書目詳細資料
發表在:Acta Neuropathol Commun
Main Authors: Raffeld, Mark, Abdullaev, Zied, Pack, Svetlana D., Xi, Liqiang, Nagaraj, Sushma, Briceno, Nicole, Vera, Elizabeth, Pittaluga, Stefania, Lopes Abath Neto, Osorio, Quezado, Martha, Aldape, Kenneth, Armstrong, Terri S., Gilbert, Mark R.
格式: Artigo
語言:Inglês
出版: BioMed Central 2020
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7346356/
https://ncbi.nlm.nih.gov/pubmed/32641156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-020-00973-y
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